Thermo Fisher Scientific LAIR1 Polyclonal Antibody
Rat LAIR1/CD305 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot에 적합합니다. 보존제가 없는 액상 형태이며, Protein A 및 항원 친화 크로마토그래피로 정제되었습니다. 단기 4°C, 장기 -20°C 보관 권장.
- 카탈로그번호
- PA581609
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1:500–1:1,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the N-terminus of the Rat LAIR1/LAIR-1/CD305 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | No preservative |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788805 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Rat LAIR1/LAIR-1/CD305.
Target Information
LAIR1 (CD305) functions as an inhibitory receptor that plays a constitutive negative regulatory role in the cytolytic function of natural killer (NK) cells, B-cells, and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of phosphatases PTPN6 and PTPN11. It reduces intracellular calcium increases evoked by B-cell receptor ligation and modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG while inducing TGF-β secretion. Also down-regulates IgG and IgE production in B-cells and IL8, IL10, and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines, preventing nuclear translocation of NF-κB p65/RELA and phosphorylation of IκBα/CHUK. Inhibits differentiation of peripheral blood precursors toward dendritic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-81609_LAIR1_CD305_P0C1X9-1_Rabbit.svg, PA5-81609_LAIR1_CD305_P0C1X9-1_Rabbit_PDP.jpeg)
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