Thermo Fisher Scientific Myelin Protein Zero/MPZ Monoclonal Antibody (MPZ/7389)
Myelin Protein Zero(MPZ)을 인식하는 Mouse monoclonal antibody로, 인간 시료에 반응합니다. IHC(P)에서 1–2 µg/mL로 사용됩니다. Protein A/G로 정제된 액상 항체로, 4°C에서 보관하며 신경세포막 단백질 분석에 적합합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MPZ/7389 |
| Immunogen | Recombinant full-length human MPZ protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Peripheral nerve cells
- Cellular Location: Membrane
Target Information
Myelin Protein Zero (MPZ), also known as Zero, is a Type I integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath to ensure stable synaptic transmission.
It constitutes approximately 50% of total protein in the peripheral myelin sheath, contributing to its structural integrity.
MPZ guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation.
Mutations (e.g., G134R) can disrupt multimer formation, cause demyelinating neuropathies, and are associated with Charcot-Marie-Tooth disease.
The cytoplasmic domain undergoes serine and tyrosine phosphorylation, particularly during peak nerve myelination.
MPZ transcript levels are moderate in brain, abundant in thymus, and highest in white matter of the CNS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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