Thermo Fisher Scientific Laminin Beta 2 Polyclonal Antibody
Laminin Beta 2 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat에 반응하며 Protein A로 정제됨. 고순도 액상 형태로 -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Laminin Beta 2 (amino acids 1701–1798) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic side of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished: A-type and B-type lamins. A-type lamins include lamin A, lamin C, and lamin Adel 10, produced by alternative splicing from a single gene. B-type lamins include lamin B1 and lamin B2, derived from distinct genes.
Mutations in A-type lamins are associated with several rare but dominant genetic disorders, such as Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease, and Dunnigan-type familial partial lipodystrophy. A-type lamin expression correlates with cell differentiation and chromatin interaction, suggesting a regulatory role in gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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