Thermo Fisher Scientific NOTCH3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• Publications: [References not provided]

Product Specifications

Product Specific Information

• Recommended positive controls: HeLa
• Predicted reactivity: Mouse (100%), Rat (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

NOTCH3 is the third discovered human homologue of the Drosophila melanogaster type I membrane protein notch. In Drosophila, notch interaction (with its cell-bound ligands delta and serrate) establishes an intercellular signaling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in humans.
NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

⚠ WARNING
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(원본 이미지 파일명: PA5-28082_NOTCH3_Q9UM47-1_Rabbit.svg, PA5-28082_NOTCH3_Q9UM47-1_Rabbit_PDP.jpeg)