Thermo Fisher Scientific PEG3 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total PEG3 protein.

Target Information

In humans, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5′ exons and a common promoter and both genes are paternally expressed. Alternative splicing events connect their shared 5′ exons either with the remaining four exons unique to ZIM2 or with the remaining two exons unique to PEG3.
In contrast, in other mammals, ZIM2 does not undergo imprinting, and in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons.
Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has shown tumor suppressor activity and involvement in tumorigenesis of glioma and ovarian cells. Alternative splicing of the PEG3 gene results in multiple transcript variants encoding distinct isoforms.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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