Thermo Fisher Scientific LRRC19 Polyclonal Antibody
Human 및 Mouse에 반응하는 LRRC19 단백질에 대한 Rabbit Polyclonal Antibody. Western Blot 및 Immunocytochemistry에 적합. 항원 친화 크로마토그래피로 정제된 액상 형태, 1 mg/mL 농도. 세포 신호전달 및 면역 반응 연구용.
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Thermo Fisher Scientific LRRC19 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid peptide near the carboxy terminus of human LRRC19 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154158 |
Product Specific Information
- Suggested positive control: K562 cell lysate
- PA5-20914 can be used with blocking peptide PEP-1028
Target Information
LRRC19 is a member of the extracellular leucine-rich repeat superfamily, involved in cell adhesion, signaling, and innate immunity. It is closely related to Toll-like receptors (TLRs), especially TLR3.
Although LRRC19 lacks a cytoplasmic Toll/IL-1 receptor (TIR) domain, it can activate NF-kappa-B and induce proinflammatory cytokine production after stimulation with TLR3 and other TLR ligands.
This suggests LRRC19 may play a role in pathogen recognition and immune response.
It has also been proposed as a potential biomarker for pancreatic tumor sensitivity to the Src inhibitor AZD0530.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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