Thermo Fisher Scientific TERT Monoclonal Antibody (2C4)
TERT 단백질을 인식하는 Mouse IgM 단클론 항체로, WB, IHC, ICC, Flow, IP, ChIP 등 다양한 실험에 사용 가능. 인간, 생쥐, 랫트 반응성. 고순도 액상 형태로 제공되며, 세포 노화 및 텔로머레이스 연구에 적합.
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Thermo Fisher Scientific TERT Monoclonal Antibody (2C4)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | View 1 publication |
| Immunohistochemistry (IHC) | - | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 | View 2 publications |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
| Flow Cytometry (Flow) | 1:50–1:200 | - |
| Immunoprecipitation (IP) | 1:10–1:500 | - |
| ChIP assay (ChIP) | Assay-Dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Cynomolgus monkey, Human, Mouse |
| Host / Isotype | Mouse / IgM |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C4 |
| Immunogen | Full-length recombinant hTERT from insect cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | IgM |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153210 |
Product Specific Information
Suggested positive control:
- 293T whole cell lysates
- HeLa whole cell lysates
- Antigen standard for TERT (transient overexpression lysate)
Target Information
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat.
Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.
Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase (TERT) have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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