Thermo Fisher Scientific DMP1 Polyclonal Antibody
DMP1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(Paraffin)에서 검증됨. 인간, 생쥐, 비인간 영장류에 반응. Affinity chromatography로 정제된 액상 항체이며, PBS/glycerol buffer에 보관. 연구용으로만 사용 가능.
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- PA5103323
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DMP1 (Accession Q13316), corresponding to amino acid residues D478–Y513 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852668 |
Product Specific Information
This antibody detects endogenous levels of total DMP1.
Target Information
Dentin matrix acidic phosphoprotein (DMP1) is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein (SIBLING) family. It is essential for proper mineralization of bone and dentin and is expressed in various bone and tooth tissue cells.
The protein includes multiple acidic domains, phosphorylation sites, an RGD cell attachment sequence, and a DNA-binding domain. In undifferentiated osteoblasts, DMP1 acts as a nuclear protein regulating osteoblast-specific gene expression. During osteoblast maturation, it becomes phosphorylated and exported to the extracellular matrix, facilitating mineralized matrix formation.
Mutations in the DMP1 gene can lead to autosomal recessive hypophosphatemia, resulting in rickets and osteomalacia. The gene structure is conserved among mammals, and two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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