Thermo Fisher Scientific DMP1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total DMP1.

Target Information

Dentin matrix acidic phosphoprotein (DMP1) is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein (SIBLING) family. It is essential for proper mineralization of bone and dentin and is expressed in various bone and tooth tissue cells.
The protein includes multiple acidic domains, phosphorylation sites, an RGD cell attachment sequence, and a DNA-binding domain. In undifferentiated osteoblasts, DMP1 acts as a nuclear protein regulating osteoblast-specific gene expression. During osteoblast maturation, it becomes phosphorylated and exported to the extracellular matrix, facilitating mineralized matrix formation.
Mutations in the DMP1 gene can lead to autosomal recessive hypophosphatemia, resulting in rickets and osteomalacia. The gene structure is conserved among mammals, and two transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.