Thermo Fisher Scientific HYOU1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human HYOU1. Recombinant protein control fragment (Product #RP-95153). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HYOU1,uniProtId:Q9Y4L1-1,ncbiNodeId:9606,antigenRange:199-346,antigenLength:999,antigenImageFileName:PA5-61925_HYOU1_Q9Y4L1-1_Rabbit.svg,antigenImageFileNamePDP:PA5-61925_HYOU1_Q9Y4L1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642599

Product Specific Information

Immunogen sequence: VLQLINDNTA TALSYGVFRR KDINTTAQNI MFYDMGSGST VCTIVTYQMV KTKEAGMQPQ LQIRGVGFDR TLGGLEMELR LRERLAGLFN EQRKGQRAKD VRENPRAMAK LLREANRLKT VLSANADHMA QIEGLMDDVD FKAKVTRV

Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.

Target Information

HYOU1 belongs to the heat shock protein 70 family. The protein is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.