Thermo Fisher Scientific NEDD4 Polyclonal Antibody, Biotin
NEDD4 단백질을 인식하는 Thermo Fisher Scientific의 Biotin 결합 폴리클로날 항체. Western blot, IHC, ELISA, IP 등 다양한 응용에 적합. Rabbit IgG로 제작되었으며, 고순도의 친화 크로마토그래피 정제 제품. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 840–880 on rat Nedd4 protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The E3 ubiquitin-protein ligase NEDD4 is a ubiquitin-like (Ubl) conjugation pathway protein containing one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It participates in the degradation of VEGFR-2/KDFR independently of its ubiquitin-ligase activity and acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, similar to the Mdm2–p53 pathway. NEDD4 is also involved in viral budding and regulation of epithelial Na⁺ channels, contributing to arterial hypertension. It is localized to the sarcolemmal region of muscle fibers, and increased expression is associated with muscle unloading and denervation, as well as decreased Notch1 expression, functioning as a down-regulator of Notch-1 gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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