Thermo Fisher Scientific CFTR Polyclonal Antibody
CFTR 단백질을 인식하는 산양 유래 폴리클로날 항체로, 사람 시료에 반응합니다. IHC(P)에서 2.5 µg/mL 농도로 검증되었으며, 0.5 mg/mL 농도의 액상 형태로 제공됩니다. TBS(pH 7.3) 버퍼에 0.5% BSA 포함, -20°C 보관 권장. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA5142139
- 판매단위
- pk
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 2.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence QRSPLEKASVVSK-C (aa 2–14) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932797 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance factor (CFTR), a cAMP-regulated chloride channel. Approximately 70% of all CF cases involve deletion of phenylalanine at position 508 (ΔF508), resulting in abnormal chloride transport. This mutation often leads to lung and liver disease. Interestingly, Salmonella typhi utilizes CFTR to enter intestinal epithelial cells, and ΔF508 heterozygote and homozygote mice show 86% and 100% reductions, respectively, in S. typhi intestinal submucosal uptake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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