Thermo Fisher Scientific ITFG2 Polyclonal Antibody
ITFG2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot에 최적화되어 있습니다. 인간 및 생쥐 시료에 반응하며, Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며 -20°C에서 장기 보관 가능합니다.
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Applications
- Western Blot (WB): 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ITFG2 (Accession Q969R8), corresponding to amino acid residues L198–R248 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852788 |
Product Specific Information
Antibody detects endogenous levels of total ITFG2.
Target Information
As part of the KICSTOR complex, ITFG2 functions in the amino acid-sensing branch of the TORC1 signaling pathway. It recruits the GATOR1 complex to lysosomal membranes, enabling interaction with GATOR2 and RAG GTPases. ITFG2 acts upstream of RAG GTPases and is required to negatively regulate mTORC1 signaling in the absence of amino acids. Without the KICSTOR complex, mTORC1 remains constitutively localized to the lysosome and activated. The KICSTOR complex may also be involved in glucose-mediated regulation of mTORC1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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