Thermo Fisher Scientific DCT Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human DCT if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DCT,uniProtId:P40126-1,ncbiNodeId:9606,antigenRange:252-401,antigenLength:519,antigenImageFileName:PA5-52741_DCT_P40126-1_Rabbit.svg,antigenImageFileNamePDP:PA5-52741_DCT_P40126-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2640430

Product Specific Information

Immunogen sequence: NECDVCTDQL FGAARPDDPT LISRNSRFSS WETVCDSLDD YNHLVTLCNG TYEGLLRRNQ MGRNSMKLPT LKDIRDCLSL QKFDNPPFFQ NSTFSFRNAL EGFDKADGTL DSQVMSLHNL VHSFLNGTNA LPHSAANDPI FVVLHSFTDA

Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 52%.

Target Information

The TYR-related proteins, TRP1 and TRP2, are also specifically expressed in melanocytes, and they likewise contribute to the synthesis of melanin within the melanosomes. The TRPs, including TYR, all share a similar transmembrane region, contain two metal-binding regions and a cysteinerich epidermal growth factor motif, and are localized in the melanosomal membrane. These proteins, however, have distinct catalytic activity, and they individually contribute to the biosynthesis of melanin biopolymers. The TRPs are believed to exist as a multi-enzyme complex, as these proteins form aggregates together, and the expression of TRP1 also helps stabilize TYR in melanocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.