Thermo Fisher Scientific TFRC Monoclonal Antibody (OTI6H9), TrueMAB
TFRC 단백질을 인식하는 Mouse IgG2b 단일클론 항체로, Western Blot에 최적화되어 있습니다. 인간 TFRC 전체 길이 단백질을 면역원으로 사용하며, 고순도 Affinity chromatography로 정제되었습니다. -20°C에서 안정적으로 보관 가능합니다.
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Applications
Tested Application
- Western Blot (WB): 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6H9 |
| Immunogen | Full-length human recombinant TFRC protein (produced in HEK293T cells) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is recycled to the cell surface, returning to neutral pH and losing affinity for the receptor.
Transferrin receptor is essential for erythrocyte and nervous system development. Serum transferrin receptor (sTfR) serves as a marker for detecting erythropoietin (EPO) misuse and diagnosing various anemias including those associated with rheumatoid arthritis, pregnancy, irritable bowel syndrome, and HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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