Thermo Fisher Scientific ITFG2 Monoclonal Antibody (OTI3A5), TrueMAB
Human ITFG2 단백질을 표적으로 하는 Mouse IgG1 형 단클론 항체로, Western blot에 최적화되어 있습니다. Affinity chromatography로 정제된 액상형 항체이며, PBS/BSA/glycerol buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A5 |
| Immunogen | Full length human recombinant protein of human ITFG2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.67 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
As part of the KICSTOR complex, ITFG2 functions in the amino acid-sensing branch of the TORC1 signaling pathway. It recruits the GATOR1 complex to lysosomal membranes, enabling its interaction with GATOR2 and RAG GTPases. ITFG2 acts upstream of RAG GTPases to negatively regulate mTORC1 signaling in the absence of amino acids. Without the KICSTOR complex, mTORC1 remains constitutively localized to lysosomes and activated. The complex may also play a role in mTORC1 regulation by glucose.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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