Thermo Fisher Scientific PSMD11 Polyclonal Antibody
Thermo Fisher Scientific의 PSMD11 폴리클로널 항체는 인간 PSMD11 단백질을 인식하며 WB, IHC, ICC/IF 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제된 비결합 액상 항체로, 높은 특이성과 재현성을 제공합니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human PSMD11 (Recombinant protein control fragment, Product #RP-105425) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662002 |
Product Specific Information
Immunogen sequence:
AAVVEFQRAQS LLSTDREASI DILHSIVKRD IQENDEEAVQ VKEQSILELG SLLAKTGQAA ELGGLLKY
Highest antigen sequence identity to the following orthologs:
- Mouse: 100%
- Rat: 100%
Target Information
The 26S proteasome (PSMD11) is a multicatalytic proteinase complex composed of a 20S core and a 19S regulator.
- The 20S core consists of four rings of 28 non-identical subunits (two rings of 7 alpha and two rings of 7 beta subunits).
- The 19S regulator includes a base with 6 ATPase and 2 non-ATPase subunits, and a lid with up to 10 non-ATPase subunits.
Proteasomes are widely distributed in eukaryotic cells and cleave peptides in an ATP/ubiquitin-dependent, non-lysosomal pathway.
A modified proteasome, the immunoproteasome, is essential for processing class I MHC peptides.
PSMD11 is a non-ATPase subunit of the 19S regulator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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