Thermo Fisher Scientific NAT1 Monoclonal Antibody (OTI1G1), TrueMAB
Human NAT1 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot 및 IHC(P) 실험에 적합. Lyophilized 형태로 제공되며, PBS buffer에 trehalose 포함. 연구용으로 세포 내 NAT1 단백질 검출 및 약물 대사 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G1 |
| Immunogen | Full length human recombinant protein of human NAT1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882)
Target Information
Arylamine N-acetyltransferases (NAT-1 and NAT-2) catalyze N- or O-acetylation of heterocyclic and arylamine substrates, contributing to the detoxification of various drugs.
Certain alleles with high N-acetyltransferase activity are associated with colon and urinary bladder cancers, as NATs can bioactivate carcinogens.
Both NAT-1 and NAT-2 are cytoplasmic proteins involved in detoxification of arylamine and hydrazine drugs.
N-acetylation polymorphism is linked to drug action and toxicity in liver tissues.
Human NAT-1 is the functional homolog of rodent NAT-2, while human NAT-2 corresponds to rodent NAT-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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