Thermo Fisher Scientific GTF3C3/TFIIIC102 Polyclonal Antibody
Human GTF3C3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 1 mg/mL 농도. 4°C 보관, 연구용 전용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 100 and 150 of human general transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
RNA polymerase (Pol) III synthesizes tRNA, 5S rRNA, 7SL RNA, and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. To maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, requiring the TFIIIB and TFIIIC2 transcription factor complexes.
The TFIIIC2 complex is composed of five subunits (TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90, and TFIIIC63), which are overexpressed in adenovirus-transformed and malignant cells such as ovarian carcinomas. TFIIIC2 recruits RNA Pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells.
The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1), and TFIIIB, all of which are upregulated in transformed cells. In many carcinomas, tumor suppressors retinoblastoma (RB) and p53 are inactivated, affecting their ability to bind and inactivate TFIIIB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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