Thermo Fisher Scientific GTF3C3/TFIIIC102 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

RNA polymerase (Pol) III synthesizes tRNA, 5S rRNA, 7SL RNA, and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. To maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, requiring the TFIIIB and TFIIIC2 transcription factor complexes.

The TFIIIC2 complex is composed of five subunits (TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90, and TFIIIC63), which are overexpressed in adenovirus-transformed and malignant cells such as ovarian carcinomas. TFIIIC2 recruits RNA Pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells.

The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1), and TFIIIB, all of which are upregulated in transformed cells. In many carcinomas, tumor suppressors retinoblastoma (RB) and p53 are inactivated, affecting their ability to bind and inactivate TFIIIB.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.