Thermo Fisher Scientific PAK5/PAK6 Polyclonal Antibody
PAK5/PAK6 단백질을 검출하는 Thermo Fisher Scientific의 폴리클로날 항체입니다. 인간, 마우스, 랫트 반응성. Western blot에 적합하며, 고순도의 Affinity chromatography로 정제됨. PBS/50% 글리세롤 버퍼에 보관, -20°C 저장.
- 판매단위
- pk
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Thermo Fisher Scientific PAK5/PAK6 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PAK5/6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900351 |
Product Specific Information
This antibody detects endogenous levels of total PAK5/6.
Target Information
PAK5, a member of the PAK family of protein kinases, contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus. PAK5 preferentially binds to CDC42 in the presence of GTP, and the CRIB motif is essential for this interaction.
PAK6 protein cotranslocates into the nucleus with androgen receptor, a steroid hormone-dependent transcription factor important for male sexual differentiation and development, in response to androgen. PAK6 was initially identified as an androgen receptor in a yeast two-hybrid screen and is highly expressed in testis and prostate tissues. Subsequent studies show that PAK6 is activated by MAP kinase kinase 6 and p38 MAP kinase, suggesting a role in cellular stress response pathways.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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