Thermo Fisher Scientific ZFHX1B Monoclonal Antibody (2D9)
ZFHX1B 단백질을 인식하는 Mouse IgG2a monoclonal antibody로 Western blot 및 ELISA에 사용 가능. Human 시료 반응성. PBS buffer에 보존, preservative 없음. -20°C에서 보관하며 freeze/thaw cycle은 피해야 함.
- 카탈로그번호
- H00009839-M01
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2D9 |
| Immunogen | ZFHX1B (NP_055610.1, 1115–1214 a.a) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SITPQGYSDS EERESMPRDG ESEKEHEKEG EDGYGKLGRQ DGDEEFEEEE EESENKSMDT DPETIRDEEE TGDHSMDDSS EDGKMETKSD HEEDNMEDGM
Target Information
ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor interacting with activated SMADs. Like ZEB1, ZEB2 inhibits transcription of the E-cadherin gene and induces epithelial-mesenchymal transition (EMT), regulating cell migration during embryonic development and wound healing. ZEB2 also protects cells from DNA damage-induced apoptosis, suggesting its role in tumor progression. Its cytoplasmic localization in various cancer tissues indicates regulation of localization in normal and tumor tissues. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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