Thermo Fisher Scientific GPR17 Monoclonal Antibody (OTI17C1)
GPR17 단백질을 인식하는 마우스 단클론 항체로, IHC(P) 실험에 적합합니다. 인간 시료에 반응하며, 액상 형태로 제공됩니다. 고순도 친화 크로마토그래피 정제 및 안정적인 PBS/BSA/glycerol 버퍼에 보관됩니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150–1:600
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI17C1 |
| Immunogen | Synthetic peptide within Human GPR17 C-terminal |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724387 |
Target Information
The G-protein-coupled receptor (GPCR) superfamily includes approximately 600–1,000 members and represents the largest known class of molecular targets with therapeutic relevance.
GPR17 is an orphan G protein-coupled receptor involved in the regulation of oligodendrocyte differentiation and myelination in the central nervous system.
It is expressed in the brain, kidney, heart, and umbilical vein endothelial cells.
GPR17 exhibits dual specificity for uracil nucleotides and cysteinyl leukotrienes and signals through G(i) to inhibit adenylyl cyclase.
It may mediate brain damage by nucleotides and cysteinyl leukotrienes following ischemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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