Thermo Fisher Scientific ACVR1B Monoclonal Antibody (2E12)
Human ACVR1B 단백질을 인식하는 Mouse IgG1 단일클론 항체. Western blot과 ELISA에 최적화된 연구용 시약. 고순도 친화 크로마토그래피 정제. PBS buffer에 보존제로 없이 제공되며 -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 0.03 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E12 |
| Immunogen | ACVR1B (AAH00254, 24 a.a. ~126 a.a.) partial recombinant protein with GST tag (MW of GST tag alone = 26 KDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SGPRGVQALL CACTSCLQAN YTCETDGACM VSIFNLDGME HHVRTCIPKV ELVPAGKPFY CLSSEDLRNT HCCYTDYCNR IDLRVPSGHL KEPEHPSMWG PVE
Target Information
ACVR1B is a serine/threonine kinase involved in signal transduction and cellular communication. Several truncated ACVR1B isoforms are exclusively expressed in human pituitary tumors. Mutations of ACVR1B have been observed in pancreatic adenocarcinomas.
Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors.
ACVR1B encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and polyadenylation result in 3 described transcript variants. A potential fourth variant contains an alternative exon 8 and lacks exons 9–11, but its mRNA expression has not been confirmed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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