Thermo Fisher Scientific TORC2 Polyclonal Antibody
TORC2 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot, ICC/IF, Flow cytometry에 사용 가능. 인간 및 랫트 반응성. 0.5 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-DPAVEDSFRSDRLQ (aa 679–692) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933325 |
Product Specific Information
This antibody has been tested in Peptide ELISA with an antibody detection limit dilution of 1:64,000.
Target Information
CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB) 2), and the related protein CRTC1 are potent CREB coactivators exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions. Studies suggest that their phosphorylation and nuclear/cytoplasmic shuttling play an important role in regulating gluconeogenesis by cAMP.
CRTC2 is present in both B and T lymphocytes and abundantly expressed in the thymus. Its activity is crucial for regulating the expression of genes involved in cellular energy metabolism, while CRTC1 is essential for energy balance and fertility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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