Thermo Fisher Scientific PD-1 Polyclonal Antibody
PD-1 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 적합. 고순도 항원 친화 크로마토그래피 정제. 인간 시료 반응성, 액상 형태, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–5 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–20 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 5–20 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein Programmed Cell Death Protein 1 (PD-1, CD279), amino acid range 41–132 of target protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903852 |
Target Information
Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC). Activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from APCs.
PD-1 binds two related ligands, PDL-1 and PDL-2. Upon binding, PD-1 generates inhibitory signals that suppress immune activation in the absence of danger signals (e.g., LPS or pathogen-associated molecules).
PD-1 deficiency in mice leads to hyperactivated immune responses and autoimmune diseases.
Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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