Thermo Fisher Scientific SLC9A7 Polyclonal Antibody
SLC9A7 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 최적화되어 있습니다. 세포 내 pH 조절 및 Na+/H+ 교환 연구에 적합하며, 액상 형태로 제공되고 -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the internal region of human SLC9A7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2556044 |
Target Information
Na⁺/H⁺ exchangers (NHE) are plasma membrane intrinsic proteins that mediate the exchange of Na⁺ and H⁺ ions in various tissues. They play a critical role in:
- Regulation of intracellular pH (pHi)
- Trans-cellular absorption of Na⁺
- Cell volume regulation
- Cell proliferation
These functions are associated with several pathophysiological states such as hypertension, organ growth, hypertrophy, cancer regression, and renal or intestinal disorders.
At least seven NHE isoforms (NHE1–7) have been identified, sharing similar primary structures with 10–12 predicted transmembrane domains. The C-terminal domain is predicted to be intracellular.
NHE7 (human, 725 aa, chromosome Xp11.4) is ubiquitously expressed and predominantly localized to the trans-Golgi network. It mediates the influx of Na⁺ or K⁺ in exchange for H⁺ and shows approximately 70% similarity to NHE6 but only about 25% homology with other NHE isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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