Thermo Fisher Scientific SLC8A2 Polyclonal Antibody
SLC8A2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 시료에 반응하며 IHC(P) 실험에 최적화됨. 항원 친화 크로마토그래피로 정제된 액상 항체로, 장기 보관 시 -20°C에서 안정적. 연구용으로만 사용 가능.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SLC8A2. Recombinant protein control fragment (Product #RP-98990). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647565 |
Product Specific Information
- Immunogen sequence: PANDSDTSTG GCQGSYRCQP GVLLPVWEPD DPSLGDKAA
- Highest antigen sequence identity: Mouse – 85%, Rat – 95%
Target Information
Sodium/calcium exchanger proteins are integral membrane proteins primarily seen in cardiac cells. In cardiac myocytes, Ca²⁺ concentration alternates between low levels during relaxation and high levels during contraction.
The Na⁺/Ca²⁺ exchanger 1 (NCX1) mediates Ca²⁺ extrusion from cardiac cells during relaxation. Four NCX1 isoforms (NCX1.1, NCX1.3, NCX1.7, and NCX1.10) result from alternate splicing.
NCX1 mRNA is highly expressed in the heart and at lower levels in the brain. NCX2 is most abundantly expressed in the brain, unlike NCX1, which is also found in heart, kidney, lung, smooth and skeletal muscle.
Differences in expression reflect distinct functional roles. Regulation mechanisms for these exchangers are not yet fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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