Thermo Fisher Scientific IKIP Monoclonal Antibody (2D5)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

ELISA (ELISA)

0.1 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

2D5

Immunogen

IKIP (NP_710154.1, 1 a.a. approximately 377 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IKBIP,uniProtId:Q70UQ0-1,ncbiNodeId:9606,antigenRange:1-350,antigenLength:350,antigenImageFileName:H00121457-M02_IKBIP_Q70UQ0-1_House_mouse.svg,antigenImageFileNamePDP:H00121457-M02_IKBIP_Q70UQ0-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MSEVKSRKKS GPKGAPAAEP GKRSEGGKTP VARSSGGGGW ADPRTCLSLL SLGTCLGLAW FVFQQSEKFA KVENQYQLLK LETNEFQQLQ SKISLISEKL ESTESILQEA TSSMSLMTQF EQEVSNLQDI MHDIQNNEEV LTQRMQSLNE KFQNITDFWK RSLEEMNINT DIFKSEAKHI HSQVTVQINS AEQEIKLLTE RLKDLEDSTL RNIRTVKRQE EEDLLRVEEQ LGSDTKAIEK LEEEQHALFA RDEDLTNKLS DYEPKVEECK THLPTIESAI HSVLRVSQDL IETEKKMEDL TMQMFNMEDD MLKAVSEIME MQKTLEGIQY DNSILKMQNE LDILKEKVHD FIAYSSTGEK GTLKEYNIEN KGIGGDF

Target Information

IKIP (Inhibitor of nuclear factor kappa-B kinase-interacting protein, IKK-interacting protein) is a single-pass membrane protein that shares a common promoter with APAF1. APAF1 and IKIP are both induced by X irradiation, however, the two gene products are transcribed in different directions. The IKIP gene is believed to be a target for p53 as expression of IKIP has been shown to promote apoptosis. IKIP has four known isoforms, three of which are found traversing the endoplasmic reticulum membrane. IKIP isoform 4 has a deletion of the transmembrane region which leads to a homogenous distribution of the protein within the cell. The IKIP gene products are expressed in vascular endothelial cells, while the isoform 4 has also been detected in lung, kidney, spleen, thymus and skeletal muscle.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.