Thermo Fisher Scientific IKIP Monoclonal Antibody (2D5)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 0.1 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MSEVKSRKKS GPKGAPAAEP GKRSEGGKTP VARSSGGGGW ADPRTCLSLL SLGTCLGLAW FVFQQSEKFA KVENQYQLLK LETNEFQQLQ SKISLISEKL ESTESILQEA TSSMSLMTQF EQEVSNLQDI MHDIQNNEEV LTQRMQSLNE KFQNITDFWK RSLEEMNINT DIFKSEAKHI HSQVTVQINS AEQEIKLLTE RLKDLEDSTL RNIRTVKRQE EEDLLRVEEQ LGSDTKAIEK LEEEQHALFA RDEDLTNKLS DYEPKVEECK THLPTIESAI HSVLRVSQDL IETEKKMEDL TMQMFNMEDD MLKAVSEIME MQKTLEGIQY DNSILKMQNE LDILKEKVHD FIAYSSTGEK GTLKEYNIEN KGIGGDF

Target Information

IKIP (Inhibitor of nuclear factor kappa-B kinase-interacting protein, IKK-interacting protein) is a single-pass membrane protein that shares a common promoter with APAF1.
APAF1 and IKIP are both induced by X irradiation, however, the two gene products are transcribed in different directions.
The IKIP gene is believed to be a target for p53 as expression of IKIP has been shown to promote apoptosis.
IKIP has four known isoforms, three of which are found traversing the endoplasmic reticulum membrane.
IKIP isoform 4 has a deletion of the transmembrane region which leads to a homogeneous distribution of the protein within the cell.
The IKIP gene products are expressed in vascular endothelial cells, while the isoform 4 has also been detected in lung, kidney, spleen, thymus, and skeletal muscle.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.