Thermo Fisher Scientific ORMDL1 Polyclonal Antibody
Human ORMDL1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합하며, 항원 친화 크로마토그래피로 정제됨. Alzheimer’s disease 및 천식 관련 연구에 활용 가능.
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Thermo Fisher Scientific ORMDL1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ORMDL1. Recombinant protein control fragment (Product #RP-105362) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2665011 |
Product Specific Information
Immunogen sequence:
FETPDQGKARL LTHWEQLDYG VQFTSSR
Highest antigen sequence identity to the following orthologs:
- Mouse: 96%
- Rat: 93%
Target Information
The ORMDL (ORM1-like) family includes ORMDL1, ORMDL2, and ORMDL3, which may play roles in gamma-secretase complex maturation.
Localized to the endoplasmic reticulum membrane, ORMDLs are widely expressed and implicated in Presenilin (PSI) expression, which is involved in Alzheimer’s disease (AD).
Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a potential therapeutic target for AD.
ORMDLs have also been identified as potential risk factors for childhood asthma.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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