Thermo Fisher Scientific SBP2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total SECISBP2.

Target Information

Eukaryotes require a selenocysteine (Sec) insertion sequence (SECIS) element in the 3′ untranslated region of the mRNA to decode the UGA codon as Sec.
SECIS-binding protein 2 (SBP-2) specifically binds selenoprotein mRNAs to form a functional complex and is essential for the insertion of Sec into selenoproteins.
Purified SBP-2 interacts specifically with the SECIS element in the phospholipid hydroperoxide glutathione peroxidase mRNA. SBP-2 shows binding activity in the liver and testis as well as hepatoma cells.
SBP-2 binds to a conserved RNA binding domain shared with several ribosomal proteins and eukaryotic translation termination release factor 1.
A second domain located N-terminal to the RNA binding domain required for Sec insertion allows SBP-2 to stably associate with the ribosomal fraction of cells.
SBP-2 preferentially stimulates incorporation directed by the selenoprotein P and phospholipid hydroperoxide glutathione peroxidase SECIS elements.
SBP-2 may have a distinct function in selecting the ribosomes for Sec insertion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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