Thermo Fisher Scientific SETX Polyclonal Antibody
SETX 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC, Flow, IP 등 다양한 응용에 사용 가능. Human 및 Mouse 반응성. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:10–1:1,000 |
| Immunoprecipitation (IP) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A genomic peptide made to an internal portion of the human Senataxin protein (between residues 600–750) [UniProt Q7Z333] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2718840 |
Target Information
Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by modulating RNA Polymerase II (Pol II) binding to chromatin and through interaction with transcription-related proteins (PubMed:19515850, PubMed:21700224). Contributes to mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for resolution of R-loop RNA-DNA hybrids at G-rich pause sites downstream of the poly(A) site, enabling XRN2 recruitment and efficient RNA Pol II transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Involved in 3’ transcriptional termination of PER1 and CRY2, important for circadian rhythm regulation. Participates in DNA double-strand break response induced by oxidative stress (PubMed:17562789), and with RRP45, targets the RNA exosome complex to transcription-induced DNA damage sites (PubMed:24105744). Essential for male meiosis and gene silencing during meiotic sex chromosome inactivation (MSCI). May regulate telomeric stability via TERRA transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8 signaling and inhibits retinoic acid-induced apoptosis (PubMed:21576111).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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