Thermo Fisher Scientific LPIN1 Polyclonal Antibody
LPIN1 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot과 IHC에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 지방 대사 및 인슐린 감수성 연구에 유용합니다.
- 카탈로그번호
- PA534566
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide near the carboxy terminus of human LPIN1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551918 |
Product Specific Information
- Suggested positive control: K562 cell lysate
- PA5-34566 can be used with blocking peptide PEP-1609.
Target Information
The Lipin family of nuclear proteins includes Lipin-1, Lipin-2, and Lipin-3. These proteins contain a nuclear signal sequence, a conserved amino-terminal (NLIP) domain, and a carboxy-terminal (CLIP) domain.
LPIN1 (Lipin-1) is essential for normal adipose tissue development and metabolism. It activates PGC-1A target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation, by inducing expression of PPARA. LPIN1 also suppresses the lipogenic program and circulating lipid levels.
Overexpression of LPIN1 promotes fat accumulation and insulin sensitivity, while deficiency can cause lipodystrophy, fatty liver, hypertriglyceridemia, and insulin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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