Thermo Fisher Scientific DNER Polyclonal Antibody

Thermo Fisher Scientific DNER Polyclonal Antibody

Applications

• Western Blot (WB): 5 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: DACQRKPCQN NASCIDANEK QDGSNFTCVC LPGYTGELCQ SKIDYCILDP
• Sequence homology:
  Cow: 79%
  Dog: 86%
  Guinea Pig: 79%
  Horse: 100%
  Human: 100%
  Mouse: 100%
  Pig: 86%
  Rabbit: 93%
  Rat: 86%

Target Information

DNER (Delta-notch-like EGF-related receptor), also known as Delta-notch-like EGF repeat-containing transmembrane protein, is a neuron-specific, atypical Notch ligand expressed in dendrites and cell bodies of neurons throughout the central nervous system.
DNER contains ten extracellular EGF-like domains that are highly homologous to those of the Notch ligand, Delta. In the cerebellum, DNER is predominantly expressed in Purkinje cells.
DNER mediates neuron-glia interaction during astrocytogenesis through a direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts. This interaction activates a Deltex-dependent Notch signaling pathway in Bergmann glia and may regulate Bergmann glial morphogenesis.
DNER is crucial for the functional and morphological maturation of Bergmann glia. DNER-knockout mice are characterized by motor discoordination and cerebellum retardation in morphogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.