Thermo Fisher Scientific CD278 (ICOS) Monoclonal Antibody (C398.4A), Functional Grade, eBioscience
CD278 (ICOS) 단일클론 항체로 T 세포 활성화 및 증식 연구에 적합. 마우스 및 랫트 ICOS와 교차 반응하며, Flow Cytometry 및 기능적 분석에 사용 가능. 1 mg/mL 농도의 액상 형태로 4°C 보관. 높은 순도와 낮은 엔도톡신 수준을 보장.
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Thermo Fisher Scientific CD278 (ICOS) Monoclonal Antibody (C398.4A), Functional Grade
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 0.25 µg/test | 6 publications |
| Functional Assay (Functional) | Assay-dependent | - |
| Blocking Assay (BLOCK) | - | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Mouse |
| Host / Isotype | Armenian hamster / IgG |
| Recommended Isotype Control | Armenian Hamster IgG Isotype Control (eBio299Arm), Functional Grade |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C398.4A |
| Conjugate | Functional Grade |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
| RRID | AB_2866400 |
Additional Formats
- Unconjugated
- APC
- APC-eFluor 780
- Biotin
- FITC
- PE
- PE-Cyanine5
- PE-Cyanine7
- Super Bright 436
- Request custom conjugation available
Product Specific Information
The C398.4A monoclonal antibody reacts with ICOS (Inducible Costimulatory molecule), also known as H4/CRP-1/AILIM, and cross-reacts with mouse and rat ICOS. ICOS is a T cell-specific activation molecule, a member of the CD28/CTLA-4 family, and expressed on activated T cells. It plays a key role in T cell activation, proliferation, and humoral immune responses.
ICOS binds its ligand B7h/B7RP-1 on activated APCs, including B cells, and may have protective roles in autoimmune diseases and Th2 cell development.
C398.4A shows strong costimulation of T cell clone proliferation, intermediate costimulation on activated T cells, and weak costimulation on resting T cells. It promotes IL-10 production from pre-activated cells expressing high levels of ICOS. The epitope recognized by C398.4A does not block ICOSL binding.
Applications Reported:
- Flow cytometric analysis
- In vitro functional assays
Applications Tested:
Tested by flow cytometric analysis of Con A-stimulated mouse splenocytes. Recommended ≤ 0.25 µg/test (100 µL final volume). Optimize titration for best performance.
Storage and Handling:
Use in sterile environment.
Filtered post-manufacturing (0.2 µm).
Purity > 90% (SDS-PAGE).
Endotoxin < 0.001 ng/µg (LAL assay).
Aggregation < 10% (HPLC).
Target Information
ICOS (CD278) encodes a protein of the CD28/CTLA-4 receptor family functioning as a homodimer. It plays a crucial role in immune response regulation and cell proliferation, and is associated with disorders such as Common Variable Immunodeficiency.
For Research Use Only.
Not for diagnostic or resale use without authorization.
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