Thermo Fisher Scientific PCBP1 Monoclonal Antibody (OTI3B9), TrueMAB
인간 PCBP1 단백질을 인식하는 Mouse IgG2b 단일클론 항체로 Western blot 및 IHC(파라핀) 분석에 적합. 1 mg/mL 농도의 액상형, PBS/BSA/glycerol 기반 저장용액 포함. -20°C에서 보관하며 반복 냉동·해동을 피해야 함.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–225 of human PCBP1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues which are thought to have arisen as a result of duplication events of entire genes.
The protein encoded by this gene appears to be multifunctional. Along with PCBP-2 and hnRNPK, it corresponds to major cellular polydomains involved in RNA binding.
This encoded protein, together with PCBP-2, functions as a translational coactivator of poliovirus RNA via sequence-specific interaction with stem-loop IV of the IRES and promotes poliovirus RNA replication by binding to its 5′-terminal cloverleaf structure.
It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA.
The encoded protein is suggested to participate in formation of a sequence-specific alpha-globin mRNP complex associated with alpha-globin mRNA stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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