Thermo Fisher Scientific PYGL Polyclonal Antibody
인간 PYGL 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
- Publications: View 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500–1:1,000
- Publications: None
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
- Publications: None
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PYGL (Product # RP-88883) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.12 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2646167 |
Product Specific Information
Immunogen sequence:
MRIDDVAALD KKGYEAKEYY EALPELKLVI DQIDNGFFSP KQPDLFKDII NMLFYHDRFK VFADYEAYVK CQDKVSQLYM NPKAWNTMVL KNIAASGKFS SDRTIKEYAQ NIWNVEPSD
Antigen sequence identity:
- Mouse: 94%
- Rat: 92%
Target Information
This gene encodes a homodimeric protein that catalyzes the cleavage of α-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. It switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity is regulated by allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes for liver, brain, and muscle isozymes. The liver isozyme supports whole-body glycemic demands, while the brain and muscle isozymes serve localized needs. Mutations in liver glycogen phosphorylase cause glycogen storage disease type VI (Hers disease), leading to moderate hypoglycemia, mild ketosis, growth retardation, and hepatomegaly. Alternative splicing produces multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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