Thermo Fisher Scientific MOV10 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human MOV10. Recombinant protein control fragment (Product #RP-105859). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MOV10,uniProtId:Q9HCE1-1,ncbiNodeId:9606,antigenRange:346-478,antigenLength:1003,antigenImageFileName:PA5-65103_MOV10_Q9HCE1-1_Rabbit.svg,antigenImageFileNamePDP:PA5-65103_MOV10_Q9HCE1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2664839

Product Specific Information

Immunogen sequence: LEELQMEHDIR HYDLESVPMT WDPVDQNPRL LTLEVPGVTE SRPSVLRGDH LFALLSSETH QEDPITYKGF VHKVELDRVK LSFSMSLLSR FVDGLTFKVN FTFNRQPLRV QHRALELTGR WLLWPMLFPV AP

Highest antigen sequence identity to the following orthologs - mouse 94%, rat 95%.

Target Information

5to 3 RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3` UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol. May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). Exhibits antiviral activity against dengue virus (DENV) (PubMed:27974568). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.