Thermo Fisher Scientific MOV10 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MOV10 protein. Validated for ICC/IF applications. Antigen affinity purified and supplied as liquid in PBS with 40% glycerol. Suitable for RNA helicase and miRNA regulation research. For research use only.
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Applications
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human MOV10. Recombinant protein control fragment (Product #RP-105859) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2664839 |
Product Specific Information
Immunogen sequence:
LEELQMEHDIR HYDLESVPMT WDPVDQNPRL LTLEVPGVTE SRPSVLRGDH LFALLSSETH QEDPITYKGF VHKVELDRVK LSFSMSLLSR FVDGLTFKVN FTFNRQPLRV QHRALELTGR WLLWPMLFPV AP
Highest antigen sequence identity to the following orthologs:
- Mouse: 94%
- Rat: 95%
Target Information
MOV10 is a 5′ to 3′ RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3′ UTRs. It is required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC), including both translational repression and cleavage of complementary mRNAs. In cooperation with FMR1, MOV10 regulates miRNA-mediated translational repression by AGO2. It restricts retrotransposition of LINE-1 elements in cooperation with TUT4 and TUT7, facilitating LINE-1 uridylation. MOV10 is essential for embryonic viability and normal CNS development, suppressing retroelements in the nucleus and regulating cytoskeletal mRNAs for neurite outgrowth. It may function as an mRNP clearance factor and exhibits antiviral activity against dengue virus (DENV).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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