Thermo Fisher Scientific IL23R Monoclonal Antibody (1C12)
IL23R 단백질을 인식하는 Mouse monoclonal antibody(클론 1C12). Western blot 및 ELISA에 적합하며, 인간 시료에 반응. IL-23 수용체 연구 및 염증성 질환 관련 연구용으로 사용. 액상 형태, PBS buffer에 보존.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1C12 |
| Immunogen | IL23R (NP_653302, 553 a.a. approximately 628 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
LNQGECSSPD IQNSVEEETT MLLENDSPSE TIPEQTLLPD EFVSCLGIVN EELPSINTYF PQNILESHFN RISLLE
Target Information
IL-23R is a 629 amino acid novel subunit of the receptor for cytokine IL23A/IL23, which pairs with IL12RB1 (IL12R beta 1) and participates in IL23A signaling. It associates constitutively with Janus kinase 2 (JAK2) and binds to transcription activator STAT3 in a ligand-dependent manner.
Alternative splicing results in six isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is a potential therapeutic target in inflammatory bowel disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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