Thermo Fisher Scientific PTPN22 Monoclonal Antibody (OTI6B1), TrueMAB
PTPN22 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 IHC(Paraffin) 분석에 적합합니다. 인간 시료 반응성이 있으며, 고순도 친화성 크로마토그래피로 정제되었습니다. PBS/BSA/glycerol 완충액에 보관되며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6B1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 359–449 of human PTPN22 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein tyrosine phosphatase PTPN22 (also known as PTP22, LYP, PEP, formerly PTPN8) is a genetic variant associated with increased risk of autoimmune diseases such as type 1 diabetes and rheumatoid arthritis.
A missense SNP in PTPN22 encodes a hematopoietic-specific phosphatase known as Lyp, with the risk allele found in approximately 17% of the general Caucasian population and 28% of rheumatoid arthritis patients.
This variant may disrupt the P1 proline-rich motif critical for interaction with the SH3 domain of CSK (cytoplasmic tyrosine kinase), potentially altering normal negative regulation of T cell activation.
The CSK–PTPN22 interaction is highly specific, suggesting that PTPN22 may act as an effector and/or regulator of CSK in T cells and other hematopoietic cells.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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