Thermo Fisher Scientific CNTNAP2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: CNTNAP2.

Target Information

This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. It includes F5/8 type C, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains, and a putative PDZ binding site.
Localized at the juxtaparanodes of myelinated axons, it mediates interactions between neurons and glia during nervous system development and is involved in localization of potassium channels within differentiating axons.
This gene occupies almost 1.5% of chromosome 7 and is among the largest genes in the human genome. It is directly regulated by FOXP2, a transcription factor related to speech and language development.
Mutations or dysregulation have been implicated in neurodevelopmental disorders such as Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD, and mental retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.