Thermo Fisher Scientific XPD Polyclonal Antibody
Rabbit polyclonal antibody recognizing human XPD protein. Validated for WB and ICC/IF applications. Predicted cross-reactivity with mouse, cow, and pig. Suitable for DNA repair and transcription research. Supplied as liquid, 0.5 mg/mL concentration.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 1–100 of Human XPD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10985882 |
Product Specific Information
This antibody is predicted to react with mouse, cow, and pig based on sequence homology.
Target Information
XPD is involved in the nucleotide excision repair pathway, a mechanism to repair DNA damage. The protein encoded by this gene participates in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can cause xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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