Thermo Fisher Scientific Munc13-4 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Munc13-4 (UNC13D) for WB and ELISA. Reacts with human and mouse samples. Supplied unconjugated in PBS/glycerol buffer. Suitable for cytoplasmic and endosomal localization studies.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 891–1090 of human UNC13D (NP_9547121) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.17 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805301 |
Product Specific Information
Immunogen sequence:
LIRKYFCSRI QQQAETTSEE LGAVTVKASY RASEQKLRVE LLSASSLLPL DSNGSSDPFV QLTLEPRHEF PELAARETQK HKKDLHPLFD ETFEFLVPAE PCRKAGACLL LTVLDYDTLG ADDLEGEAFL PLREVPGLSG SEEPGEVPQT RLPLTYPAPN GDPILQLLEG RKGDREAQVF VRLRRHRAKQ ASQHALRPAP
Positive Samples:
A549, HeLa, HepG2, Mouse lung
Cellular Location:
Cytoplasm, Late endosome, Lysosome, Membrane, Peripheral membrane protein, Recycling endosome
Target Information
This gene encodes a member of the UNC13 family, similar in domain structure to other family members but lacking an N-terminal phorbol ester-binding C1 domain. Munc13-4 plays a role in vesicle maturation during exocytosis and regulates cytolytic granule secretion. Mutations are associated with familial hemophagocytic lymphohistiocytosis type 3, a rare autosomal recessive disorder.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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