Thermo Fisher Scientific CST1 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:100

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Target Information

The cystatin superfamily is a well-established family of cysteine protease inhibitors.
Cystatins A and B (type 1) are mainly intracellular; cystatins C, D, E/M, F, G, S, SN and SA cystatins are extracellular (type 2); and the kininogens are type 3 cystatins which are intravascular proteins.
All true cystatins inhibit cysteine peptidases of the papain family, such as cathepsins, and some also inhibit legumain family enzymes.

Cystatin SA, cystatin S and cystatin SN are found primarily in saliva, and cystatin S and SN can also be expressed in tears, urine and seminal fluid.
Cystatin C is expressed in brain, thymus, ovary, epididymis and vas deferens.
Cystatin D protects against proteinases in the oral cavity, while Cystatin E/M and F moderate the inhibition of cathepsin proteins.

Fetuins, part of the cystatin superfamily, are secretable proteins that influence osteogenesis and bone resorption, regulate insulin and hepatocyte growth factor receptors, and mediate systemic inflammation responses.
High molecular weight kininogen (Kininogen HC) and low molecular weight kininogen (Kininogen LC) both inhibit thrombin- and plasmin-induced aggregation of thrombocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.