Thermo Fisher Scientific Shaker Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–1 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 2–10 µg/mL

Product Specifications

Product Specific Information

• Positive control: Shaker over-expressed HEK293
• Cellular location: Membrane

Target Information

The assemblage of specific ion channels and receptors at synaptic sites is crucial for signaling between pre- and post-synaptic cells. DLG (Drosophila discs-large gene) is co-localized with Shaker K1 channels, which are clustered at glutamatergic synapses. DLG-Shaker interactions are required in vivo for shaker clustering at the neuromuscular junction. The channel protein Shaker, which is properly synthesized, glycosylated, folded, assembled, and delivered to the plasma membrane, is very important for potassium channel function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.