Thermo Fisher Scientific ACAP2 Polyclonal Antibody
ACAP2 단백질을 인식하는 Thermo Fisher Scientific의 고트 폴리클로날 항체. Western blot과 IHC(P) 적용 가능. 인간, 생쥐, 랫트 반응성. 합성 펩타이드 기반 면역원 사용. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 0.3–1 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 5–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (EKLNRFQQDSQKF) corresponding to the C-terminus amino acids of ACAP2 (aa 766–778) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10977709 |
Product Specific Information
- Predicted to react with canine and porcine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
ACAP2 is a transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain, and a PH domain.
ACAP2 acts as a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) and shows robust constitutive ARF6 GAP activity.
This activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid but has little activity toward ARF1.
ACAP2 controls the return of ARF to the inactive GDP-bound state and, along with ACAP1, is targeted by phosphatidylinositol (3,4,3) triphosphate, inhibiting PDGF-induced dorsal membrane ruffle formation in NIH3T3 fibroblasts.
ACAP2 is phosphorylated upon DNA damage, likely by ATM or ATR, and is expressed broadly with the highest levels in lung tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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