Thermo Fisher Scientific Phospho-BTK/BPK (Tyr551) Polyclonal Antibody
BTK 단백질의 Tyr551 인산화 부위를 인식하는 폴리클로날 항체로 인간 시료에 반응. IHC, ICC/IF, ELISA 등 다양한 응용에 적합. Protein A로 정제된 고순도 항체이며, -20°C에서 안정적으로 보관 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human Btk around the phosphorylation site of Tyr551 [DE(p-Y)TS] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily of tyrosine kinases. Mutations in the BTK gene have been linked to severe developmental blocks in human B-cell ontogeny and immunodeficiency disorders. BTK interacts with toll-like receptor (TLR) family members such as TLR4, 6, 8, and 9, which play crucial roles in innate and adaptive immunity. It also interacts with key proteins in TLR4 signal transduction, including MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting its involvement in lipopolysaccharide signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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