Thermo Fisher Scientific CD6 Polyclonal Antibody
Rabbit polyclonal antibody for human CD6 detection. Validated for Western blot and ELISA. High purity via affinity chromatography. Suitable for research use in T and B cell studies. Stable liquid form with glycerol buffer for long-term storage.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 424–668 of human CD6 (NP_0067163) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2901747 |
Product Specific Information
- Positive Samples: MCF7, Jurkat, U-937, HT-29, Raji
- Immunogen sequence:
LRIKGKYALP VMVNHQHLPT TIPAGSNSYQ PVPITIPKEV FMLPIQVQAP PPEDSDSGSD SDYEHYDFSA QPPVALTTFY NSQRHRVTDE EVQQSRFQMP PLEEGLEELH ASHIPTANPG HCITDPPSLG PQYHPRSNSE SSTSSGEDYC NSPKSKLPPW NPQVFSSERS SFLEQPPNLE LAGTQPAFSA GPPADDSSST SSGEWYQNFQ PPPQPPSEEQ FGCPGSPSPQ PDSTDNDDYD DISAA
Target Information
CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL).
It interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and acts as a coreceptor for T cell activation and stabilizer of the immunological synapse.
CD6-ALCAM mediated adhesion is important for T cell proliferation and may function via association with CD5, fine-tuning CD5 signaling.
Ligation of CD6 has an anti-apoptotic role in chronic lymphocytic leukemia B cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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