Thermo Fisher Scientific CD6 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 424-668 of human CD6 (NP_0067163) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CD6,uniProtId:P30203-1,ncbiNodeId:9606,antigenRange:424-668,antigenLength:668,antigenImageFileName:PA5-117117_CD6_P30203-1_Rabbit.svg,antigenImageFileNamePDP:PA5-117117_CD6_P30203-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.6 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2901747

Product Specific Information

Positive Samples: MCF7, Jurkat, U-937, HT-29, Raji

Immunogen sequence: LRIKGKYALP VMVNHQHLPT TIPAGSNSYQ PVPITIPKEV FMLPIQVQAP PPEDSDSGSD SDYEHYDFSA QPPVALTTFY NSQRHRVTDE EVQQSRFQMP PLEEGLEELH ASHIPTANPG HCITDPPSLG PQYHPRSNSE SSTSSGEDYC NSPKSKLPPW NPQVFSSERS SFLEQPPNLE LAGTQPAFSA GPPADDSSST SSGEWYQNFQ PPPQPPSEEQ FGCPGSPSPQ PDSTDNDDYD DISAA

Target Information

CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. CD6 may exert some its functions via association with CD5, probably by fine-tuning CD5 signaling. Ligation of CD6 has antiapoptotic role in chronic lymphocytic leukemia B cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.