Thermo Fisher Scientific NUDT1 Monoclonal Antibody (5F11)
NUDT1 단백질을 인식하는 Thermo Fisher Scientific의 단일클론 항체로, Western blot과 ELISA에 적합합니다. Human 시료에 반응하며, Mouse IgG2a 아이소타입입니다. 고순도 친화 크로마토그래피로 정제되었으며, -20°C에서 보관합니다.
- 카탈로그번호
- H00004521-M02
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific NUDT1 Monoclonal Antibody (5F11)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5F11 |
| Immunogen | NUDT1 (AAH14618, 1 a.a. ~179 a.a) full-length recombinant protein with GST tag (MW of GST tag = 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
MSGISPQQMG EPEGSWSGKN PGTMGASRLY TLVLVLQPQR VLLGMKKRGF GAGRWNGFGG KVQEGETIED GARRELQEES GLTVDALHKV GQIVFEFVGE PELMDVHVFC TDSIQGTPVE SDEMRPCWFQ LDQIPFKDMW PDDSYWFPLL LQKKKFHGYF KFQGQDTILD YTLREVDTV
Target Information
Oxygen radicals damage chromosomal DNA causing cell death and inducing mutations. Among the various classes of DNA damage caused by oxygen radicals, an oxidized form of guanine base (8-oxoguanine) appears to be important as it can pair with cytosine and adenine, leading to G:C to T:A transversion mutations.
A significant amount of 8-OxoG is formed in mammalian chromosomal DNA, with most damaged nucleotides excised and excreted in urine. Along with 8-oxoG in DNA, 8-oxo-deoxyguanosine (8-oxo-dGTP) forms in the nucleotide pool during normal metabolism and oxidative stress.
8-oxo-dGTP can be incorporated into DNA during replication, causing mispairing unless repaired. MTH converts 8-oxo-dGTP to the monophosphate form, preventing misincorporation. MTH also recognizes 8-oxo-rGTP, which could incorporate into RNA, leading to missense or nonsense protein production.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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