Thermo Fisher Scientific CCR5 Polyclonal Antibody
CCR5 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. Western blot, IHC, ELISA, IP 등 다양한 응용에 적합. 인간 및 비인간 영장류, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 안정한 액상 형태로 -20°C 보관.
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Thermo Fisher Scientific CCR5 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 1–50 of human CCR5 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. CCR5 (CC-CKR-5) acts as a principal coreceptor for macrophage- and dual-tropic HIV-1 strains, facilitating fusion and entry into human white blood cells. CCR5 is essential for infection by HIV-1, HIV-2, and SIV. Beta-chemokines RANTES, MIP-alpha, and MIP-beta are ligands for CCR5 and can prevent infection by M-tropic HIV-1. CCR5 associates with the surface CD4-gp120 complex of HIV, leading to membrane fusion and viral entry. The amino-terminal domain and extracellular loops of CCR5 serve as HIV binding sites. CCR5 mRNA is expressed in lymphoid organs and monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: CCR5-501AP_CCR5_P51681-1_Rabbit.svg, CCR5-501AP_CCR5_P51681-1_Rabbit_PDP.jpeg)
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