Thermo Fisher Scientific APP Monoclonal Antibody (OTI7A10), Biotin, TrueMAB
인간 APP 단백질을 인식하는 단클론성 항체로 Biotin으로 결합된 TrueMAB 형식 제품. Luminex 등 다양한 분석에 사용 가능. 고순도 정제 및 안정적 PBS/BSA/glycerol 버퍼로 보존. 알츠하이머 연구 등 신경질환 관련 단백질 분석에 적합.
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Thermo Fisher Scientific APP Monoclonal Antibody (OTI7A10), Biotin, TrueMAB
Applications
- Luminex (LUM)
Tested Dilution
- Assay-dependent
Publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7A10 |
| Immunogen | Full length human recombinant protein of human APP produced in HEK293T cell |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 10 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
Amyloid Precursor Protein (APP) or Amyloid beta precursor protein functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. APP is important for neurite growth, neuronal adhesion, and axonogenesis. APP is a 100–140 kDa transmembrane glycoprotein that exists as several isoforms resulting from alternative splicing. Proteolytic cleavage of APP by beta- and gamma-secretases results in the generation of beta amyloid, which is the primary component of senile plaques—one of the major histopathologic features of Alzheimer’s disease. Abnormal regulation and processing of APP also plays a role in Down’s syndrome, early onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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