Thermo Fisher Scientific MICAL3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human MICAL3. Recombinant protein control fragment (Product #RP-105890). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MICAL3,uniProtId:Q7RTP6-1,ncbiNodeId:9606,antigenRange:1623-1713,antigenLength:2002,antigenImageFileName:PA5-65130_MICAL3_Q7RTP6-1_Rabbit.svg,antigenImageFileNamePDP:PA5-65130_MICAL3_Q7RTP6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2663828

Product Specific Information

Immunogen sequence: MELASGAPRPR KASSAPSQGK ERRPDSPTRP TLRGSEEPTL KHEATSEEVL SPPSDSGGPD GSFTSSEGSS GKSKKRSSLF SPRRNKKEKK

Highest antigen sequence identity to the following orthologs: Mouse - 69%, Rat - 75%.

Target Information

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.